Sicarius is a genus of spider, the best known being the six-eyed sand spider of southern Africa. It is also commonly known as assassin spiders for the relatively quick catching and killing of their prey.
Sicarius are desert and dry country spiders that mainly live in the Southern Hemisphere in South America and Africa (the single exception is the Central American S. rugosus), known primarily for their self-burying behavior. All have six eyes arranged in three groups of two (dyads). Sicarius resembles the crab spiders of the family Thomisidae and the members of the family Homalonychidae. However, Sicarius lacks the characteristic violin-shaped marking of their cousins, the recluse spiders. Individual Sicarius can live for as much as 15 years, which makes these among the longest-lived araneomorphae spiders (some tarantulas can live well over 20–30 years), and can live for a very long time without food or water.
The sicarius spiders are between one and two inches in length.
The spiders of this genus (along with the recluse spiders) have potent tissue-destroying venoms containing the dermonecrotic agent, sphingomyelinase D, which is otherwise found only in a few pathogenic bacteria. This venom is highly necrotic in effect, capable of causing lesions (open sores) as large as 2.5 cm in diameter. The genus Sicarius may have more toxic venom than Loxosceles (particularly the African species), based on laboratory experiments with rabbits. Sicariids are found in barren deserts and are able to bury themselves partially in the sand. Because of this, humans seldom come in contact with them. The females produce egg sacs covered with a mixture of sand and silk. The genus is considered to be a living fossil in that it is both quite primitive and distributed in parts of the former Gondwanaland, the huge southern continent that separated during the Mesozoic.
A U.S. patent (number 6,998,389) has been awarded for a means for using Sicariidae venom as a treatment for cancer. 
Barcode of Life Data Systems (BOLD) Stats Specimen Records:29 Specimens with Sequences:15 Specimens with Barcodes:0 Species:14 Species With Barcodes:11 Public Records:15 Public Species:11 Public BINs:0
Other sequences that do not yet meet barcode criteria may also be available.
GTAAATATGCGGATATTAGGAATATCAATGGATAAAGTTCCTTTATTTATTTGATCAGTTTTAGTAACGGCTGTATTATTATTGTTATCTCTTCCAGTTTTAGCTGGA---GCTATTACTATATTATTAACGGATCGAAATTTTAATACTTCTTTTTTTGATCCAGCTGGGGGTGGAGATCCTATTTTGTTTCAGCATTTGTTTTGGTTTTTTGGACACCCTGAGGTTTATATTTTAATTTTGCCTGGATTTGGAATTATTTCTCATGTGCTGAGATATTCTGTGGGGAAGTGT---GAACCTTTTGGTTCAATTGGTATAGTTTATGCTATAGTAGCTATTGGTTTAATAGGTTTTGTAGTATGGGCACATCATATGTTTTCTGTTGGGATAGATGTAGATACTCGTGCTTATTTTACGGCAGCTACTATAATTATTGCTGTTCCTACTGGTATTAAGGTTTTTAGATGAATT---GCTACTTTACATGGATCA---TATTTTAAGGTTGATACTTCTATCTTGTGATGTGTGGGATTTATTTTTTTATTTACGTTAGGGGGGATTACTGGGGTAGTA -- end --
ATTAATATACGAATATATGGAATAACTATAGAAAAAGTTCCTTTGTTTATTTGATCAGTTTTAGTTACTACTGTGTTATTATTACTTTCTCTTCCTGTATTAGCGGGT---GCTATTACTATGTTGTTAACTGATCGAAATTTTAATACTTCTTTTTTTGATCCAGCTGGAGGAGGGGATCCTATTTTATTTCAACATTTGTTTTGGTTTTTTGGTCATCCAGAAGTTTATATTTTGATTTTACCAGGATTTGGAATTATTTCTCATGTTTTGAGATATTCTGTTGGGAAGTGT---GAACCTTTTGGTTCTATTGGGATAATTTATGCTATGGTAGCTATTGGAGTAATAGGATTTGTAGTCTGGGCTCATCATATATTTTCTGTAGGAATGGATGTTGATACACGTGCTTATTTTACGGCAGCTACTATAGTAATTGCTGTTCCTACAGGAATTAAGGTTTTTAGATGAATTACC---ACTTTACATGGTTCT---TATTTTAAAATAGATGCTCCTATTTTATGATGTATTGGATTTATCTTTTTGTTTACGTTAGGAGGTATTACTGGAGTAGTA -- end --